Ranitidine is a potent, selective, and orally active histamine H2-receptor antagonist. It effectively inhibits gastric secretion and antagonizes histamine-induced increases in guinea-pig isolated rat atrium and relaxations of the rat isolated uterine horn. Research indicates its potential in inhibiting breast tumor development and spread in mice, as well as reducing CD11b+Ly6Chi cells and lung metastasis.
- Potent, selective, and orally active histamine H2-receptor antagonist
- Inhibits gastric secretion
- Antagonizes Histamine-induced effects in isolated heart and uterine horn
- Inhibits breast tumor development and spread
- Reduces CD11b+Ly6Chi cells and inhibits lung metastasis
- Inhibits primary tumor growth
- Increases the latency of breast tumorigenesis and reduces tumor numbers